Paludrine - meaning and definition. What is Paludrine
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What (who) is Paludrine - definition

CHEMICAL COMPOUND
Proguanil hydrochloride; Paludrine; Chloroguanide; Chlorguanide; ATC code P01BB01; Paludrin; Proguanil Chloride

proguanil         
[pr??'gw?:n?l]
¦ noun Medicine a bitter-tasting synthetic compound used in the prevention and treatment of malaria.
Origin
1940s: from propyl + biguanide + -il.

Wikipedia

Proguanil

Proguanil, also known as chlorguanide and chloroguanide, is a medication used to treat and prevent malaria. It is often used together with chloroquine or atovaquone. When used with chloroquine the combination will treat mild chloroquine resistant malaria. It is taken by mouth.

Side effects include diarrhea, constipation, skin rashes, hair loss, and itchiness. Because malaria tends to be more severe in pregnancy, the benefit typically outweighs the risk. If used during pregnancy it should be taken with folate. It is likely safe for use during breastfeeding. Proguanil is converted by the liver to its active metabolite, cycloguanil.

It is on the World Health Organization's List of Essential Medicines. In the United States and Canada it is only available in combination as atovaquone/proguanil.

Examples of use of Paludrine
1. ICI was an innovator in pesticides and in pharmaceuticals; it pioneered the first effective treatment for malaria, Paludrine, as well as the Nobel prize–winning beta–blocker drugs which have saved the lives of countless heart disease victims.